For in-vitro research use only. Not for human consumption.
Mazdutide
Mazdutide (IBI362) is a dual-acting peptide that activates both GLP-1 and glucagon receptors. Unlike Tirzepatide (GIP/GLP-1), Mazdutide pairs GLP-1 signaling with glucagon receptor agonism, which may stimulate hepatic energy expenditure and fat oxidation through distinct pathways.
Mazdutide definition
Mazdutide is a synthetic dual glucagon / GLP-1 receptor agonist peptide studied in preclinical research models for incretin and glucagon-pathway pharmacology. Structurally related to oxyntomodulin, mazdutide engages both glucagon receptors (GCGR) and GLP-1 receptors (GLP-1R) with distinct affinities. Research use only. Supplied by Nexus Laboratory with batch-level certificate of analysis documenting HPLC purity, mass spectrometry identity, and endotoxin screening.
No sequence is listed in the current catalog record for this product.
- CAS
- 2259884-03-0
- MW
- ~4400 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C207H317N45O65
- Purity
- 99.51%
- Form
- Lyophilized powder
- Class
- Dual GLP-1/Glucagon Receptor Agonist
Reconstitution calculator
Estimate vial concentration and aliquot volume from the selected vial mass, solvent volume, and target research amount.
Calculations are for lab planning only and do not replace the product COA, protocol requirements, or qualified professional review. Confirm solvent compatibility before use.
Compound details.
- CAS Number
- 2092628-22-1
- Molecular Weight
- ~4517 g/mol
- Class
- Dual GLP-1 / glucagon agonist
- Receptor targets
- GLP-1R + GCGR
Research context.
Studied in preclinical research models examining dual-receptor incretin pharmacology, glucagon-pathway signaling research, and comparator research against single-receptor agonists (semaglutide, liraglutide) and triple-receptor agonists (retatrutide). Research use only.
Verification standard.
Every Nexus Laboratory batch ships with a Certificate of Analysis documenting HPLC purity (target ≥98%), mass spectrometry identity (expected versus observed mass), and endotoxin screening — verified by third-party laboratory testing and publicly archived. Review Nexus lab verification.
Mazdutide is part of the Nexus GLP-1 & Metabolic catalog. GLP-1, amylin, and multi-agonist metabolic research peptides. Each listed variant is priced from the consolidated Nexus catalog and intended for qualified research use only.
TODO-COPY: replace with real compound-specific narrative.
The chemistry.
Dual GLP-1/glucagon receptor agonist peptide (also known as IBI362/LY3305677)
Storage: Store at -20°C (long term). Refrigerate after reconstitution.
Technical specifications.
- Product Name: Mazdutide 10mg
- Classification: Dual GLP-1/Glucagon Receptor Agonist
- Structural Description: Dual GLP-1/glucagon receptor agonist peptide (also known as IBI362/LY3305677)
- CAS Number: 2259884-03-0
- Molecular Weight: ~4400 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
HPLC trace preview.
Related research compounds
Same category, mechanism overlap, and common research stack pairings.
Mazdutide research FAQ.
What is Mazdutide used for in research?
Mazdutide is supplied for controlled in-vitro research workflows in the GLP-1 & Metabolic category. It is not labeled for human or veterinary use.
Is Mazdutide HPLC verified?
Mazdutide is listed with Nexus lab verification. Current catalog records show 99.51% purity context where batch COA data is available.
Which Mazdutide sizes are available?
Current Nexus variants include 5mg, 10mg.
Does Mazdutide include a COA?
Yes. The current Nexus record links Mazdutide to batch NEX-MAZDUTIDE-2026-0052.