For in-vitro research use only. Not for human consumption.
AICAR
AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside) is a cell-permeable nucleoside that is metabolized to ZMP (AICAR monophosphate), an AMP analog that activates AMP-activated protein kinase (AMPK). AMPK is a master regulator of cellular energy homeostasis, making AICAR a widely used pharmacological tool in metabolic research.
AICAR definition
AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside) is a cell-permeable nucleoside that is metabolized to ZMP (AICAR monophosphate), an AMP analog that activates AMP-activated protein kinase (AMPK). AMPK is a master regulator of cellular energy homeostasis, making AICAR a widely used pharmacological tool in metabolic research.
No sequence is listed in the current catalog record for this product.
- CAS
- 2627-69-2
- MW
- 258.23 Da
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C9H14N4O5
- Purity
- 99.61%
- Form
- Lyophilized powder
- Class
- AMPK Activator / Nucleoside Analog
Reconstitution calculator
Estimate vial concentration and aliquot volume from the selected vial mass, solvent volume, and target research amount.
Calculations are for lab planning only and do not replace the product COA, protocol requirements, or qualified professional review. Confirm solvent compatibility before use.
Compound details.
- CAS Number
- 2627-69-2
- Molecular Weight
- 258.23 Da
- Molecular Formula
- C₉H₁₄N₄O₅
- Class
- AMPK Activator / Nucleoside Analog
- Purity
- ≥99% purity
- Physical Form
- Lyophilized powder
- Storage
- Store at -20°C (long term). Refrigerate after reconstitution.
Research context.
AICAR is one of the most cited AMPK activators in published literature, with thousands of studies using it as a tool compound. It has been used to study fatty acid oxidation, glucose uptake, mitochondrial biogenesis, and exercise-mimetic signaling in cell culture and animal models.
Verification standard.
Every Nexus Laboratory batch ships with a Certificate of Analysis documenting HPLC purity (target ≥98%), mass spectrometry identity (expected versus observed mass), and endotoxin screening — verified by third-party laboratory testing and publicly archived. Review Nexus lab verification.
AICAR is part of the Nexus Mitochondrial & Energy catalog. Energy metabolism, redox, and mitochondrial research compounds. Each listed variant is priced from the consolidated Nexus catalog and intended for qualified research use only.
TODO-COPY: replace with real compound-specific narrative.
The chemistry.
5-Aminoimidazole-4-carboxamide ribonucleoside (nucleoside analog, not a peptide)
Storage: Store at -20°C (long term). Refrigerate after reconstitution.
Technical specifications.
- Product Name: Aicar
- Classification: AMPK Activator / Nucleoside Analog
- Structural Description: 5-Aminoimidazole-4-carboxamide ribonucleoside (nucleoside analog, not a peptide)
- CAS Number: 2627-69-2
- Molecular Weight: 258.23 Da
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
HPLC trace preview.
Related research compounds
Same category, mechanism overlap, and common research stack pairings.
AICAR research FAQ.
What is AICAR used for in research?
AICAR is supplied for controlled in-vitro research workflows in the Mitochondrial & Energy category. It is not labeled for human or veterinary use.
Is AICAR HPLC verified?
AICAR is listed with Nexus lab verification. Current catalog records show 99.61% purity context where batch COA data is available.
Which AICAR sizes are available?
Current Nexus variants include 50mg, 100mg.
Does AICAR include a COA?
Yes. The current Nexus record links AICAR to batch NEX-AICAR-2026-0007.