For in-vitro research use only. Not for human consumption.
FOXO4
FOXO4-DRI is a D-retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 transcription factors. In senescent cells, FOXO4 binds p53 to prevent apoptosis. By disrupting this interaction, FOXO4-DRI allows p53 to trigger apoptosis in senescent cells while sparing normal cells — making it a research tool for selective senolysis.
FOXO4 definition
FOXO4-DRI is a D-retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 transcription factors. In senescent cells, FOXO4 binds p53 to prevent apoptosis. By disrupting this interaction, FOXO4-DRI allows p53 to trigger apoptosis in senescent cells while sparing normal cells — making it a research tool for selective senolysis.
No sequence is listed in the current catalog record for this product.
- CAS
- 2460055
- MW
- ~4800 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C228H388N86O64
- Purity
- 99.74%
- Form
- Lyophilized powder
- Class
- Senolytic Peptide / p53-FOXO4 Interaction Inhibitor
Reconstitution calculator
Estimate vial concentration and aliquot volume from the selected vial mass, solvent volume, and target research amount.
Calculations are for lab planning only and do not replace the product COA, protocol requirements, or qualified professional review. Confirm solvent compatibility before use.
Compound details.
- CAS Number
- 2460055
- Molecular Weight
- ~4800 g/mol
- Molecular Formula
- C₂₂₈H₃₈₈N₈₆O₆₄
- Class
- Senolytic Peptide / p53-FOXO4 Interaction Inhibitor
- Purity
- ≥99% purity
- Physical Form
- Lyophilized powder
- Storage
- Store at -20°C (long term). Refrigerate after reconstitution.
Research context.
Published in Cell (Baar et al., 2017) by researchers at Erasmus University Medical Center. This landmark study demonstrated selective elimination of senescent cells in aged mouse models, generating significant interest in senolytics research.
Verification standard.
Every Nexus Laboratory batch ships with a Certificate of Analysis documenting HPLC purity (target ≥98%), mass spectrometry identity (expected versus observed mass), and endotoxin screening — verified by third-party laboratory testing and publicly archived. Review Nexus lab verification.
FOXO4 is part of the Nexus Longevity & Cellular Health catalog. Mitochondrial, senolytic, and cellular health research compounds. Each listed variant is priced from the consolidated Nexus catalog and intended for qualified research use only.
TODO-COPY: replace with real compound-specific narrative.
The chemistry.
D-retro-inverso peptide targeting FOXO4-p53 protein-protein interaction
Storage: Store at -20°C (long term). Refrigerate after reconstitution.
Technical specifications.
- Product Name: FOX04-DRI
- Classification: Senolytic Peptide / p53-FOXO4 Interaction Inhibitor
- Structural Description: D-retro-inverso peptide targeting FOXO4-p53 protein-protein interaction
- Molecular Weight: ~4800 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
HPLC trace preview.
Related research compounds
Same category, mechanism overlap, and common research stack pairings.
FOXO4 research FAQ.
What is FOXO4 used for in research?
FOXO4 is supplied for controlled in-vitro research workflows in the Longevity & Cellular Health category. It is not labeled for human or veterinary use.
Is FOXO4 HPLC verified?
FOXO4 is listed with Nexus lab verification. Current catalog records show 99.74% purity context where batch COA data is available.
Which FOXO4 sizes are available?
Current Nexus variants include 10mg.
Does FOXO4 include a COA?
Yes. The current Nexus record links FOXO4 to batch NEX-FOXO4-2026-0033.